Sarms Raw Powder S-4 Andarine Gtx-007 For Burning Fat and Gaining Strength
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|Minimum Order Quantity :||10G||Price :||Negotiable|
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|Model NO:||CAS 317318-70-0||Usage:||Building Muscle, Burning Fat And Gaining Strength|
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White SARMS Raw Powder Selective Androgen Receptor Modulator Gw-501 / 516
GW501516 (also known as GW-501,516, GW1516, GSK-516) is a PPAR& receptor agonist that was invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s, was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases, and was abandoned in 2007 because animal testing showed that the drug caused cancer to develop rapidly in several organs.
GW501516 is a selective agonist (activator) of the PPARδ receptor. It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ with > 1000 fold selectivity over PPARα and PPARγ.
In rats, binding of GW501516 to PPARδ recruits the co activator PGC-1a. The PPARδ/coactivator complex in turn up regulates the expression of proteins involved in energy expenditure. Furthermore in rats treated with GW501516, increased fatty acid metabolism in skeletal muscle and protection against diet-induced obesity and type II diabetes was observed.
In obese rhesus monkeys, GW501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL). The mechanism by which PPARδ agonists increase HDL appears to be a result of increased expression of the cholesterol transporter ABCA1
The regular dosage of Cardarine is 10 to 20 mg per day. 10 mg a day is aimed for endurance, and the higher the dosage the greater the fat loss benefits are going to be.
Expect to experience more intense endurance and fat burning when taking 20 mgs, but you never want to take much more than that.
You can take it once a day or split the dosage (in the AM and PM). GW 501516 is best taken 30-45 minutes before a workout. You'll feel the difference the first time you take it.
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