10161-33-8 Trenbolone Acetate Raw Trenbolone Powders Anti Estrogen Steroids
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Phone Number : +86 13663845045
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|Minimum Order Quantity :||50gram||Price :||Negotiable|
|Packaging Details :||Foil Bag||Delivery Time :||Within 5hours after payment|
|Payment Terms :||T/T, Western Union, MoneyGram||Supply Ability :||1000kg per week|
|Place of Origin:||China||Brand Name:||Filter-bio|
|Chemical Name:||Metribolone||Color:||Yellow Crystalline Powder|
|Delivery:||FEDEX ,DHL EMS||Other Name:||Methyl Trenbolone|
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Pharmaceutical Grade Metribolone(Methyl Trenbolone) for Lean Mass
|Hot Selling Products||CAS No.|
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Product History :
1. Methyltrienolone was first described in 1965.627 It was immediately identified as an extremely potent anabolic agent, far more potent than the commercially available agents of the time. In spite of its high relative activity, however, methyltrienolone has seen very limited use in humans. It was used clinically during the late 1960's and early '70's, most notably in the treatment of advanced breast cancer. Here, its exceedingly strong anabolic/androgenic action helps the drug counter the local effects of endogenous estrogens, lending it some efficacy for slowing or even regressing tumor growth. Such application was not long lived, however, as more realistic evaluations of the drug's toxicity soon led to its abandonment in human medicine.
2. By the mid-1970's, methyltrienolone was becoming an accepted standard in non-human research studies, particularly those pertaining to the study of the androgen receptor activity. For this purpose the agent is very well suited. Its sheer potency and resistance to serum-binding proteins makes it an excellent in-vitro receptor-binding standard to compare other agents to. Being so resistant to metabolism, active methyltrienolone metabolites are also not going to greatly interfere with the results of most experiments. Body tissues can metabolize most steroids fairly easily, which means that even incubation studies can be complicated with the question of what is causing a particular effect, the steroid or one of its unidentified metabolites.
1. Metribolone (methyltrienolone aka R1881) is a potent, non-aromatizable androgen that is structurally similar to trenbolone and has been referred to as “oral tren.” Methyltrienolone binds strongly to the androgen receptor (AR) and is a more potent agonist (activator) of the androgen receptor than is DHT. 17a-methyltrienolone is listed at 30,000 times more anabolic than methyltestosterone according to Julius Vida in “Androgens and Anabolic Agents: Chemistry and Pharmacology.” Effective dosages begin at only 25mcg.
2. Studies have shown that taking an oral anabolic steroid with food may decrease its bioavailability.630 This is caused by the fat-soluble nature of steroid hormones, which can allow some of the drug to dissolve with undigested dietary fat, reducing its absorption from the gastrointestinal tract. For maximum utilization, methyltrienolone should be taken on an empty stomach
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