Nandrolone Phenylpropionate NPP Steroids For Massive Muscle Gain 10161-33-8

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Nandrolone Phenylpropionate NPP Steroids For Massive Muscle Gain 10161-33-8

Nandrolone decanoate has been reported to induce psychiatric side effects, such as aggression and depression. Adolescence represents an extremely sensitive neurodevelopmental period to influence by detrimental effects of drug abuse. A group of investigators provide some evidence regarding the effects of nandrolone decanoate on the emotional profile of animals exposed during adolescence.

Adolescent rats received daily injections of nandrolone decanoate for 14 days. Behavioral tests such as forced swim, sucrose preference, open field and elevated plus maze tests were performed at early adulthood on separate groups of animals. In vivo electrophysiological recordings were carried out to monitor changes in electrical activity of serotonergic neurons of the dorsal raphe nucleus (DRN) and noradrenergic neurons of the locus coeruleus (LC). What the authors observed was that after early exposure to nandrolone, rats displayed depression-related behavior, characterized by increased immobility in the forced swim test and reduced sucrose intake in the sucrose preference test. In addition, adult rats presented anxiety-like behavior characterized by decreased time and number of entries in the central zone of the open field and decreased time spent in the open arms of the elevated plus maze, suggesting that nandrolone decreased the firing rate of spontaneously active serotonergic neurons in the DRN while increasing the firing rate of noradrenergic neurons in the LC. Nandrolone decanoate is not recommended in adolescents, and public health measures should be taken to prevent the abuse of this compound in the developing population

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