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Nandrolone Decanoate is an anabolic steroid that is pharmacologically classified under androgen hormones. Nandrolone is primarily indicated for the treatment of conditions that are associated with anemia but it can also be used to treat osteoporosis, chronic renal failure and mass wasting syndrome that is associated with HIV/AIDS. This agent has the ability to increase the mass and size of red blood cells and also to increase the concentration of hemoglobin in them. But, due to the recent development of the recombinant human erythro-proteins, the use of Nandrolone Decanoate for the treatment of anemic conditions as a result of renal failure has greatly diminished. In many cases, this drug has been a subject of serious drug abuse and misuse. In most of these circumstances, it leads to negative effects like hepatotoxicity, antisocial behavioral changes, changes in libido and higher chances of acquiring cardiovascular diseases. Nandrolone has masculinization effects on women but they are totally reversible. This drug was approved for clinical use in 1983 and it was listed under controlled substances in 1991.
What is Nandrolone’s mode of action?
Nandrolone Decanoate has the same mechanisms of action as any other androgen hormones such as testosterone. Nandrolone Decanoate is an exogenous androgen that facilitates the anabolism of proteins and it stimulates an appetite for food, this leads to a reversed action of catabolic processes in the body and a negative nitrogen balance. Nandrolone Decanoate can be used to increase bone density in osteoporosis patients and to increase the lean body mass in patients with cachexia e.g. patients who are malnourished from dialysis. Androgens also have a great effect on; the production of erythrocytes, calcium balance and adjusting blood sugar levels. An increased production of erythrocytes is due to an increased production of the ESF- Erythropoietic Stimulating Factor. After a treatment using this medication, patients with anemia that is associated with renal diseases will note an increased volume of hemoglobin and red blood cells in their systems.
Because of the androgynous effects that Nandrolone Decanoate exhibits, it should never be administered to young children since it can facilitate the abnormal development of sexual characteristics. It can also lead to some serious disturbances to normal growth. This medication can lead to undesired effects on women since endogenous hormones inhibit the synthesis and production of the gonadotropin releasing hormone which initiates a negative feedback mechanism on the pituitary that facilitates a reduced gonadotropic function. All these processes result in a substantial reduction of the endogenously produced luteinizing hormone, testosterone, and follicle stimulating hormone. Endogenous hormones can also affect the testes directly. Other effects of these hormones can include a decrease in high-density lipoprotein concentration and an increase in low-density lipoproteins.
The Pharmacokinetics of Nandrolone Decanoate
Nandrolone Decanoate is usually administered intramuscularly and once it gets to the circulatory system, it goes through rapid hydrolysis that is effected by plasma esterases, after that, it dissociates into free Nandrolone particles which are highly soluble in lipids, so they are quickly dissolved into the body cells where they affect their actions. After its action in the cells, it undergoes metabolism in the liver through oxidation and reduction processes that are similar to those of other androgens such as testosterone. Information on exactly how the metabolites of this agent are excreted is still inconclusive but when in the plasma, it clears off at a rate of 1.6L/h/Kg and it has an elimination half-life of 3 to 6 days.