Other Name(s): Stenabolic
Half-Life: 24 hours
SR9009, also known as Stenabolic, is a selective androgen receptor modulator (SARM) that has been referred to as ‘exercise in a bottle’. Initial trials on mice showed an increase in muscle and metabolic rate without exercise, and enhanced stamina with exercise. Essentially, SR9009 has shown promise to improve endurance and metabolism to become leaner.
SR9009 was first developed by Professor Thomas Burris from The Scripps Research Institute. Initial findings were published in the journal Nature Medicine in 2012, with studies showing that Stenabolic significantly increases exercise endurance in animal models.
The compound affects the core biological clock, synchronizing the body’s circadian rhythm with the 24-hour cycle of day and night.
HOW SR-9009 WORKS
The compound SR9009 works by binding to one of the body’s naturally occurring molecules, called Rev-Erbα. This molecule influences lipid and glucose metabolism in the liver, the production of fat-storing cells, and the response of macrophages (cells that remove dead or dying cells) during inflammation.
The study showed that mice lacking Rev-Erbα had decreased muscle metabolic activity and running capacity. However, Burris’ group demonstrated that activation of Rev-Erbα using Stenabolic led to increased metabolic activity in skeletal muscle in both culture and mice. The difference was a 50% increase in running capacity for mice treated with SR9009 – even when exercise was restricted.
Professor Burris explained that the study resulted in animals developing muscles just like an athlete who has been training, even when they haven’t. He believes that Rev-Erbα affects muscle cells through the creation of new mitochondria, and the removal of defective mitochondria via macrophages.
Basically, SR-9009 is one of the strongest endurance boosters out there. It is often compared to GW-5051516 (Cardarine) because the benefits are comparable.
There are 7 primary benefits of SR9009 that have been observed in both initial studies and user-reported reviews.
SR9009 increases weight loss
Stenabolic shows great promise in increasing weight loss, even without exercise – which is why it’s being touted as “exercise in a bottle”.
In initial studies, researchers chose mice with low skeletal muscle and metabolism to treat with SR9009. Over a 30-day study, the muscle and metabolic rate of the mice increased, even when they weren’t allowed to exercise.
Increased mitochondria activity was noted in muscle, as well as an increase in macrophages – cells that remove dying or dead cells – enhancing the energy output of the animal’s muscles to create athletic, oxidative muscle without any actual exercise.
Due to this increase in muscle activity, SR9009 helped the body burn calories instead of turning them into fat, effectively allowing an increase in weight loss.
SR9009 increases stamina and endurance
Additional to muscle conditioning, initial studies showed that once the mice that were treated with Stenabolic for 30 days were allowed to exercise, they showed a 50% increase in endurance – running longer and covering more distance than controls. 
This may be due to an increase in the glucose oxidation in skeletal muscle, allowing the body to go faster for longer with a higher level of strength and stamina.
SR9009 may lower blood cholesterol
Mice treated with SR9009 for 7-10 days showed reduced blood levels of triglycerides and total cholesterol. 
Another study  suggested that targeting Rev-Erbα may be an effective method for suppressing LDL cholesterol levels using SR9009. Over an 8-week period, genetically modified mice with a similar fat profile to humans were treated with SR9009, resulting in a significant decrease in total cholesterol, triglycerides, and LDL cholesterol.
SR9009 indicates a decrease in inflammation
Stimulation of Rev-Erbα activity by SR9009 was shown to greatly diminish ventilator-induced lung edema and inflammatory cells in rats. 
The study suggests that the circadian rhythm affects the immune response, which may exacerbate inflammation. As Rev-Erbα plays a role in regulating the circadian rhythm, SR9009 may help reduce inflammation by activating Rev-Erbα.
SR9009 may increase wakefulness
Due to its ability to activate Rev-Erbα, Stenabolic can affect the wakefulness of mice. As it affects the circadian rhythm, when SR9009 was injected into mice during periods they usually sleep, they were kept awake longer and had less REM sleep.
However, when the mice were injected with SR9009 during their normal awake hours, there was no perceptible change in their behavior.
This suggests that Stenabolic may be useful for sleep-related disorders such as narcolepsy or shift workers.
SR9009 may reduce heart disease
Studies show that both normal and genetically modified older mice had improved heart function when injected with SR9009. Mice with surgically-induced heart growth (hypertrophy) showed a reduction in heart size and weight without affecting their blood pressure after two weeks of treatment with SR9009.
SR9009 may effectively reduce anxiety
Mice injected with SR9009 twice per day for 3 to 10 days showed decreased anxiety-like behavior. Interestingly, it has been suggested that SR9009 was as effective as a benzodiazepine, even though it shows the potential to increase stamina and endurance of athletes.
TIPS FOR SR-9009 DOSAGE
The best SR9009 dosage should be roughly 30 to 40mg per day for a 10-12 week cycle. If you personally think that SR9009 dosage is too high, you can always start out with 10 to 20mg to see how you react to the compound. Although keep in mind that SR9009 has a very short half-life, so maybe that would not be the best idea.
I personally have yet to try SR9009, but from what I have read the SR9009 dosage is significantly higher than other SARMs. For other SARMs such as GW-501516 or MK-2866, the recommended dosage is roughly 20mg. The great thing with SR9009 is that you will not be shut down, it does not have ANY impact on your natural hormone levels at all.
As there are no clinical studies yet on human dosing, these are guidelines only and users should adjust their dose by 10mg to find their sweet spot. Always make sure to build the SR9009 dosage up gradually.
Due to the short half-life of SR9009, it is recommended to spread the dose across 3-4 times per day. Let’s say you are taking 40mg of SR9009, this means that you will have to take 10mg every 4 hours. This is essential, the drug needs to be stable within your body to produce the best results.
With other SARMs, you can get away with dosing once a day but unfortunately with your SR9009 dosage that is not the case. What’s also great about SR9009 is that it is used by both male and females.
30-40mg per day
30-40mg per day
If you want my advice regarding the best SR9009 dosage, start out small and build your dose up gradually. You can just start out by taking 10mg a day and see where that takes you.
This anabolic drug has a short half-life i.e. around 4 hours. However, this does not mean that you should take a dose every 4 hours.
The ideal dosage for Sr9009 is 40 mg per day. You can split this dose into 2 or more intervals. It is recommended to take a dose of 1 to 2 hours before physical activity.
In addition, the recommended cycle duration for Sr9009 is 12 weeks maximum. Also, when you complete one cycle, make sure you take a 4 weeks break before starting the next one and take proper PCT meanwhile.