High Purity Muscle Repair Supplements IGF-1 Insulin-Like Growth Factor-1

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Insulin-like growth factor-1 (IGF-1) is a hormone that functions as the major mediator of growth hormone (GH)-stimulated somatic growth, as well as a mediator of GH-independent anabolic responses in many cells and tissues. IGF-1 is a small peptide (molecular weight 7647) that circulates in serum bound to high affinity binding proteins. IGF-1 is an unusual peptide in this regard since it is more than 99 percent protein-bound.

IGF-1 is synthesized by multiple mesenchymal cell types. As a result, there are two major mechanisms of IGF-1 regulation:

●IGF-1 that is synthesized in the liver and secreted into the blood is under the control of GH.

●Autocrine/paracrine IGF-1 is synthesized in peripheral tissues, such as bone. Its synthesis is controlled by GH and by factors that are secreted locally by the surrounding cell types. Some of the secreted autocrine/paracrine IGF-1 enters into the systemic circulation. Therefore, understanding the regulation of autocrine/paracrine synthesis of IGF-1 is necessary to interpret changes in serum IGF-1 concentrations.

IGF-1 exerts its effects via activation of the IGF-1 receptor [1]. This receptor is widely distributed, which enables blood-transported IGF-1 to coordinate balanced growth among multiple tissues and organs. In contrast, autocrine/paracrine IGF-1 can stimulate local, unbalanced growth independently of systemic GH. Examples of this type of growth regulation are wound healing and growth of the contralateral kidney after unilateral nephrectomy.

What do my test results mean?

Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you.

IGF-1 measurements are adjusted for age because levels tend to decrease as you get older.

Results of IGF-1 are given in nanograms per milliliter (ng/mL). Normal ranges vary by age.

For diagnosing acromegaly:

• If your IGF-1 is normal, but your GH is low, you likely don't have acromegaly.

• If your IGF-1 is high and your GH is high, you may have acromegaly.

Levels of IGF-1 that are higher or lower than normal may also be caused by:

• Hypothyroidism, or low thyroid hormone levels

• Liver disease

• Uncontrolled diabetes mellitus