—— Samuel William
—— Peter Hunt
—— Belinda Raman
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|Product Name:||MGF, Mechano Growth Factor||Purity:||>98%|
|Specification:||2mg||Storage:||2-8 Degree Centigrade Refrigerator|
|Synonyms:||Mechano Growth Factor, IGF-1 Ec|
Mechano Growth Factor 2mg MGF Powder 100% Delivery Peptide Hormone
Mechano growth factor (MGF) is a novel splice variant of the Insulin-Like Growth Factor-1 (IGF-1), also known as IGF-1 Ec in humans and IGF-1Eb in rodents. It is actually originally called MGF because the RNA form of it is expressed in muscle tissues in response to the overload or/and damage of muscle growth tissue. The C-terminal peptide of the mechano growth factor (MGF) is a crucial region for the alternative splicing of the peptide. The alternative splicing in the MGF is brought about by the shift in the reading frame in which a specific C-terminal sequence (E-domain) is encoded by exon 5 and the first part of the exon 6. Another interesting point in MGF is that, because of the E domain it contains, MGF can act on muscles independently from the rest of the molecule. Furthermore, MGF can elicit very different effects with mGF promoting satellite cells proliferation and IGF-1 inducing differentiation (Dluzniewska et al. 2005).
The physiological role of MGF has been well studied on the cellular model in vitro and in mice. In contrast to IGF-1 growth factor causes mechanical mainly division dormant muscle cells by activation of different receptors. Reduced synthesis MGF - this is the main reason that results in the reduction of muscle mass in dystrophic patients and the elderly.
|Product name||MGF, Mechano Growth Factor|
|Form & Formulations||Sterile Filtered white lyophilized (Freeze-Dried)|
|Purity||>98% by RP-HPLC|
|Water Content||≤ 7.0% by Karl Fischer|
|Acetate Content||≤ 10.0% by RP-HPLC|
|Bacterial Endotoxins||≤ 5EU/mg|
|Storage||2-8 degree centigrade refrigerator|
|Pacakge||1kit=10vials Alumnium foil+bubble+carton
MGF was suggested to play a number of physiological roles because the failure in its expression may result to age-related loss of skeletal function. Included in its functions is its ability to become a potent neuroprotective as supported by the study that has shown functional copies of the MGF cDNA to be expressed in a plasmid vector which then protected facial neurons after nerve damage (Dluzniewska et al. 2005). One such failure is called sarcopenia. It would also appear that with regards to age, the young have a better ability to respond to MGF (4), and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.
When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene is released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. The appearance of MGF also initiates the upregulation of new protein synthesis. After this initial splicing of IGF-1 into MGF, production then switches towards producing a systemic release of IGF-1Ea from the liver, which also upregulates protein synthesis as well. The expression of IGF-1 splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary mechanism by which the body produces new muscle tissue.